Clinical spectrum and molecular pathophysiology of Shwachman–Diamond syndrome

Pre-engraftment syndrome: clinical significance and pathophysiology

In 2003, the Takaue group observed clinical features such as fever, skin rash and fluid retention that mimicked engraftment syndrome (ES) in cord blood transplantation (CBT) patients who received reduced-intensity conditioning regimens, and referred to this event as an "early inflammatory syndrome (EIS)" (personal communication). Around the same time, we also observed these manifestations in pa...

3. Clinical Manifestations and Pathophysiology 3.1 Spectrum of Dengue Infection

Clinical Spectrum of PRKAG2 Syndrome.

Salicylate intolerance: pathophysiology, clinical spectrum, diagnosis and treatment.

INTRODUCTION Acetylic salicylic acid (aspirin) intolerance relates to altered generation and metabolism of arachidonic acid and eicosanoids, and prostaglandins and leukotrienes ingestion of salicylates or COX-inhibitors. METHODS Selective review of literature in PubMed and the Cochrane Library. RESULTS Rhinitis, asthma and nasal polyposis are typical presentations, but urticaria and gut inf...

Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms.

Emerging evidence suggests that increased dietary consumption of fructose in Western society may be a potentially important factor in the growing rates of obesity and the metabolic syndrome. This review will discuss fructose-induced perturbations in cell signaling and inflammatory cascades in insulin-sensitive tissues. In particular, the roles of cellular signaling molecules including nuclear f...